Menzies R, Heron L, Lampard J, McMillan M, Joseph T, Chan J, Storken A, Marshall H. A randomised controlled trial of SMS messaging and calendar reminders to improve vaccination timeliness in infants. Vaccine. 2020 Mar 30;38(15):3137-3142. doi: 10.1016/j.vaccine.2020.02.045. Epub 2020 Mar 5. PMID: 32147296. [Childhood Vaccination NPM]
Intervention Components (click on component to see a list of all articles that use that intervention): Text Messaging
Intervention Description: The study had four intervention groups: (1) SMS text message reminders only, (2) personalized calendar reminder only, (3) SMS text message and personalized calendar (both interventions), and (4) no intervention. The SMS text message reminders were sent to parents or carers of infants to remind them of upcoming immunization appointments. The personalized calendar reminder was a printed calendar that was given to parents or carers of infants, which included the infant's immunization schedule and appointment dates. The calendar was personalized with the infant's name and photo. The intervention groups were compared to a control group that received no intervention ,[object Object],.
Intervention Results: The study found that there was a statistically significant improvement in on-time vaccination only at the 12-month schedule point among infants who received SMS reminders alone or in combination with a personalized calendar compared to the control group. However, there were no statistically significant impacts of calendar interventions alone. The study also reported a high rate of on-time compliance among control participants, which increased after the implementation of the 'No Jab, No Pay' policy ,[object Object],. Additionally, the study found that there were no statistically significant effects of any intervention at the 4, 6, or 18-month schedule points. It was noted that failure to send SMS messages, parents electing to 'STOP' receiving the SMS messages, incorrect infant dates of birth, and random errors contributed to the failures to deliver SMS messages ,[object Object],. The study also highlighted limitations, such as the relatively low number of infants contributing to the 4-month outcomes, the study sample being more compliant than the national population, and the study being powered to detect differences between the four randomized groups. Post-hoc analyses on smaller subgroups may have been limited by insufficient power ,[object Object],. Overall, the study found encouraging but mixed results for the ability of SMS messages to improve on-time compliance with the infant immunization schedule ,[object Object],.
Conclusion: SMS reminders are more effective in improving timeliness where pre-existing compliance is lower, but the 18 month schedule point appeared to be less amenable to intervention. Australia and New Zealand Clinical Trial Registration No. ACTRN12614000970640.
Study Design: The study design was a randomized controlled trial (RCT) ,[object Object],. Participants were randomly assigned to one of four intervention groups in a 1:1:1:1 ratio, using permuted blocks of size eight. The four intervention groups were: (1) SMS text message reminders only, (2) personalized calendar reminder only, (3) SMS text message and personalized calendar (both interventions), and (4) no intervention ,[object Object],.
Setting: The setting for the study was conducted in Australia, specifically in Sydney and Wollongong in New South Wales (NSW) and Adelaide in South Australia (SA) ,[object Object],.
Population of Focus: The target audience for the study included parents or carers of infants aged less than 16 months who were attending participating immunization provider sites for any reason and who possessed a mobile phone and sufficient English language skills ,[object Object],.
Sample Size: The required sample size for the study was estimated as 1600 subjects, based on 80% power to reject the null hypothesis of no intervention effectiveness at a 5% level for significance ,[object Object],. A total of 1594 eligible infant/carer pairs were recruited into the study ,[object Object],.
Age Range: The study included infants aged less than 16 months ,[object Object],. The age range of the enrolled infants was from 11 November 2013 to 16 November 2015, with the majority of infants being born in 2014 and 2015 ,[object Object],.
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