Battarbee, A. N., Sandoval, G., Grobman, W. A., Reddy, U. M., Tita, A., Silver, R. M., El-Sayed, Y. Y., Wapner, R. J., Rouse, D. J., Saade, G. R., Chauhan, S. P., Iams, J. D., Chien, E. K., Casey, B. M., Gibbs, R. S., Srinivas, S. K., Swamy, G. K., Simhan, H. N., & Eunice Kennedy Shriver National Institute of Child Health Human Development Maternal-Fetal Medicine Units (MFMU) Network (2021). Maternal and Neonatal Outcomes Associated with Amniotomy among Nulliparous Women Undergoing Labor Induction at Term. American journal of perinatology, 38(S 01), e239–e248. https://doi.org/10.1055/s-0040-1709464 Evidence Rating: Emerging Intervention Components (click on component to see a list of all articles that use that intervention): HEALTH_CARE_PROVIDER_PRACTICE, Active Management of Labor, Prolonged Second Stage of Labor Intervention Description: RCT. Maternal and neonatal outcomes were compared among women with amniotomy versus women with intact membranes and no amniotomy at 6 2-hour time intervals: before oxytocin initiation, 0 to <2 hours after oxytocin, 2 to <4 hours after, 4 to <6 hours after, 6 to <8 hours after, and 8 to <10 hours after Intervention Results: Of 6,106 women in the parent trial, 2,854 (46.7%) women met inclusion criteria. Of these 2,340 (82.0%) underwent amniotomy, and majority of the women had amniotomy performed between 2 and <6 hours after oxytocin. Cesarean delivery was less frequent among women with amniotomy 6 to <8 hours after oxytocin compared with women without amniotomy (21.9 vs. 29.7%; adjusted odds ratio 0.61, 95% confidence interval 0.42-0.89). Amniotomy at time intervals ≥4 hours after oxytocin was associated with lower odds of labor duration >24 hours. Amniotomy at time intervals ≥2 hours and <8 hours after oxytocin was associated with lower odds of maternal hospitalization >3 days. Amniotomy was not associated with postpartum or neonatal complications. Conclusion: Among a contemporary cohort of nulliparous women undergoing term labor induction, amniotomy was associated with either lower or similar odds of cesarean delivery and other adverse outcomes, compared with no amniotomy. Setting: Hospitals Population of Focus: Nulliparous women undergoing induction of labor with oxytocin at or after 38 weeks' pregnancy. Access Abstract
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